Longevity factor klotho and chronic psychological stress
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor 23/klotho axis in chronic kidney disease.
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates phosphate and 1,25-hydroxyvitamin D [1,25(OH)2D] metabolism. FGF23 binds to FGF receptor 1 with its coreceptor Klotho and maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In addition, FGF23 reduces the synthesis and accelerates the degradation of 1,25(OH)2D to reduce int...
متن کاملKlotho and chronic kidney disease.
Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by secretases and released into the circulation to act as endocrine factor. Unlike membrane Klotho which functions as a coreceptor for fibroblast growth factor-23 (FGF23) to modulate FGF23 signal transduction, soluble Klotho is a multifunction...
متن کاملSkeletal muscle as a regulator of the longevity protein, Klotho
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies, a direct relationship between circulating K...
متن کاملFGF23 and Klotho in chronic kidney disease.
PURPOSE OF REVIEW The wealth of data regarding fibroblast growth factor-23 (FGF23) and Klotho in chronic kidney disease (CKD) has risen exponentially over the past decade. This review is an attempt to summarize pivotal aspects of previous research, provide an update of recent findings and define important areas for future investigation. RECENT FINDINGS The phosphaturic hormone FGF23 increases...
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As people advance into their 80s, mental health becomes ever more important. Two nonsmoking octogenarians of identical age and gender, with the same body mass index, type of diet and physical exercise routine, may have markedly different prospects of living to 100. Cognitive and social functioning, and positive well-being, are key to living longer. Many activities that influence longevity are v...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2015
ISSN: 2158-3188
DOI: 10.1038/tp.2015.81